PCH213: PROCESS DEVELOPMENT AND SCALE-UP STUDIES |
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Course Objective: To learn the basics of process development and scale-up from bench scale to the production scale.
Introduction: Description and evolution of a process system, Fundamental principles of mathematical modeling, Dimensional analysis, Homogeneous reactor scale-up.
Reactors for Fluid Phase Processes Catalyzed by Solids: Pseudo-homogeneous and heterogeneous models, Two-dimensional models, Scale up considerations.
Fluid-fluid Reactors: Scale-up considerations in packed bed absorbers and bubble columns, Applicability of models to scale-up.
Mixing Processes: Scale-up relationships, Scale-up of polymerization units, Continuous stages gas-liquid slurry processes, Liquid-liquid emulsions.
Fluidized Beds: Major scale-up issues, Prediction of performance in large equipment, Practical commercial experience, Problem areas.
Continuous Mass Transfer Operations: Fundamental considerations, Scale-up procedure for distillation, absorption, stripping and extraction units.
Solid-Liquid Separation Processes: Fundamental considerations, Small scale studies for equipment design and selection, Scale-up techniques, Uncertainties.
Course Learning Outcomes (CLO):
1. Understand the basis of scale-up criteria
2. Ability to scale-up homogeneous and heterogeneous reactors
3. Ability to scale-up mixing and fluidization systems
4. Ability to scale-up mass transfer processes
Recommended Books:
1. Bisio, A., and Kabel, R.L., Scale up of Chemical Processes, John Wiley (1985).
2. Johnstone, R. E., and Thring, M. W., Pilot Plants, Models and Scale-up Methods in Chemical Engineering, McGraw-Hill (1957).