PCH113 PROCESS DEVELOPMENT AND SCALE-UP STUDIES |
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Course Objective:
To learn the basics of process
development and scale-up from bench scale to the production scale.
Introduction: Description and evolution of a
process system, Fundamental principles of mathematical modeling, Dimensional
analysis, Homogeneous reactor scale-up.
Reactors for Fluid
Phase Processes Catalyzed by Solids: Pseudo-homogeneous and heterogeneous models,
Two-dimensional models, Scale up considerations.
Fluid-fluid Reactors: Scale-up considerations in packed bed
absorbers and bubble columns, Applicability of models to scale-up.
Mixing Processes: Scale-up relationships, Scale-up of polymerization units, Continuous
stages gas-liquid slurry processes, Liquid-liquid emulsions.
Fluidized Beds: Major scale-up issues, Prediction of
performance in large equipment, Practical commercial experience, Problem areas.
Continuous Mass
Transfer Operations: Fundamental
considerations, Scale-up procedure for distillation,
absorption, stripping and extraction units.
Solid-Liquid Separation
Processes: Fundamental
considerations, Small scale studies for equipment design and selection, Scale-up
techniques, Uncertainties.
Recommended Books:
1.
Bisio, A., and Kabel, R.L., Scale up of Chemical
Processes, John Wiley (1985).
2.
Johnstone, R. E., and Thring, M. W., Pilot Plants,
Models and Scale-up Methods in Chemical Engineering, McGraw-Hill (1957).